The Center for AI Large Foundation Models focuses on advancing fundamental and applied research, breaking through key theories and core technologies of large models, and driving the deep application of generative AI in fields such as healthcare, law, and intelligent devices. The center places high importance on the study of foundational theories and algorithms in AI, delving into areas such as the mathematical theory of large models, optimization algorithm design and analysis, and machine learning-assisted algorithms, aiming to provide solid theoretical support for ongoing advancements in AI and its downstream applications. The center’s self-developed HuatuoGPT has successfully achieved intelligent and precise medical services, making it the first Chinese medical foundation model in the country to integrate both academic and industrial applications. Additionally, it has developed an intelligent assessment system in the judicial field, using high-dimensional data fusion and intelligent algorithms to achieve real-time data integration and accurate assessments across departments, enhancing the level of intelligence in building a law-based society. Furthermore, the center has created a globally leading Arabic generative pre-training model and automatic speech recognition technology, supporting international collaboration under the “Belt and Road” framework. The center will continue to explore AI technology, actively promoting its widespread application and industrialization, contributing to the intelligent and sustainable development of society and supporting the economic and social growth of the Guangdong-Hong Kong-Macao Greater Bay Area.